1,1'-Carbonyldiimidazole → HCID 62588378, compound

Participants

Reaction Steps

0.76 g (7.31 mmol) 3-methoxypropionic acid in 10 ml dry DMF were treated with 1.25 g (7.71 mmol) 1,1′-carbonyl-diimidazole and stirred for 1 hr at room temperature. 1.00 g 3-aminobenzylalcohol were added and stirring was continued over night. The solvent was removed and the residue chromatographed on silica in ethyl acetate, yielding 1.26 g N-(3-Hydroxymethyl-phenyl)-3-methoxy-propionamide.

Provenance & Evidence