HCID 62588378, compound → HCID 86618326, compound

HRID 506581Notes

Reaction equation

HRID 506581 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:15])[CH2:11][CH2:12][O:13][CH3:14])[CH:6]=[CH:7][CH:8]=1>CC(C)=O.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:15])[CH2:11][CH2:12][O:13][CH3:14])[CH:6]=[CH:7][CH:8]=1)=[O:1]

Participants

4

Reactant 1

HCID 62588378HCID 62588378, compound

Product 1

HCID 86618326HCID 86618326, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Procedure

The above 1.26 g N-(3-Hydroxymethyl-phenyl)-3-methoxy-propionamide were dissolved in 50 ml acetone, 12.60 g manganese dioxide were added and the mixture stirred at room temperature over night. The mixture was filtered and the filtrate evaporated and further purified by chromatography on silica in ethyl acetate/heptane mixtures.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated
  3. customfurther purified by chromatography on silica in ethyl acetate/heptane mixtures

Sources & evidence

ORD record
ord-fccb4d9c1b5b4eeb97b040c462a6a4c9
Source dataset
uspto-grants-2010_08
Patent number
US07786113B2

Reaction notes

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