HCID 13292919, compound → HCID 178452909, compound

HRID 506587Notes

Reaction equation

HRID 506587 reaction equation
[C:1]1([C:7]2[NH:16][C:10]3=[N:11][CH:12]=[C:13]([NH2:15])[CH:14]=[C:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:18]([O:20][CH:21]([CH:23]=[CH2:24])[CH3:22])=[O:19]>N1C=CC=CC=1.ClCCl.O>[CH3:22][CH:21]([O:20][C:18](=[O:19])[NH:15][C:13]1[CH:14]=[C:9]2[N:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[NH:16][C:10]2=[N:11][CH:12]=1)[CH:23]=[CH2:24]

Participants

6

Reactant 2

HCID 13292919HCID 13292919, compoundHCID 178508009HCID 178508009, compound

Product 1

HCID 178452909HCID 178452909, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

80 mg 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine (0.38 mmol,) in 3 ml dry pyridine were treated with a solution of 3-buten-2-yl chloroformate in dichloromethane. The mixture was stirred at room temperature over night, diluted with 1 ml water and stirred for another hr. The solvents were evaporated and the residue was dispersed in water with sonication, filtered, and the filter residue washed thoroughly with water and ether.

Workup

  1. stirringstirred for another hr
  2. customThe solvents were evaporated
  3. additionthe residue was dispersed in water with sonication
  4. filtrationfiltered
  5. washthe filter residue washed thoroughly with water and ether

Sources & evidence

ORD record
ord-fc08b83e49d7436fb938071f3c630d09
Source dataset
uspto-grants-2010_08
Patent number
US07786113B2

Reaction notes

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