4-(2-(Diethylamino)-Ethoxy)-Benzaldehyde → HCID 178464071, compound

HRID 506589Notes

Reaction equation

HRID 506589 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH2:10]([N:12]([CH2:24][CH3:25])[CH2:13][CH2:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1)[CH3:11]>[N+](C1C=CC=CC=1)([O-])=O>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[C:20]([C:19]3[CH:22]=[CH:23][C:16]([O:15][CH2:14][CH2:13][N:12]([CH2:24][CH3:25])[CH2:10][CH3:11])=[CH:17][CH:18]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 4116744-(2-(Diethylamino)-Ethoxy)-BenzaldehydeHCID 6911565-Bromopyridine-2,3-diamine

Product 1

HCID 178464071HCID 178464071, compound

Reagents, catalysts & solvents 1

HCID 7416NitrobenzeneSolvent

Procedure

3.31 g 5-bromo-2,3-diaminopyridine and 3.90 g 4-(2-diethylamino-ethoxy)benzaldehyde in 120 ml nitrobenzene were heated to 140-150° C. for 24 hrs. The solvent was removed by vacuum distillation. The residue was dispersed in ethyl acetate and the crude product was isolated by filtration and washed thoroughly with more ethyl acetate.

Workup

  1. customThe solvent was removed by vacuum distillation
  2. additionThe residue was dispersed in ethyl acetate

Sources & evidence

ORD record
ord-e331928a39394467844b995abc0c1460
Source dataset
uspto-grants-2010_08
Patent number
US07786113B2

Reaction notes

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