5-Bromopyridine-2,3-diamine → HCID 178422994, compound

HRID 506590Notes

Reaction equation

HRID 506590 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH3:10][C:11]1[CH:16]=[C:15]([C:17](O)=O)[CH:14]=[CH:13][N:12]=1>O>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[C:17]([C:15]3[CH:14]=[CH:13][N:12]=[C:11]([CH3:10])[CH:16]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 6911565-Bromopyridine-2,3-diamineHCID 27628212-Methylpyridine-4-carboxylic acid

Product 1

HCID 178422994HCID 178422994, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.30 g 5-bromo-2,3-diaminopyridine and 0.212 g 2-methyl-pyridine-4-carboxylic acid were heated in 3 g polyphosphoric acid at 160° C. with stirring for 16 hrs. The mixture was diluted with water and insoluble components removed by filtration. Water was evaporated from the filtrate and the residue dispersed in pyridine. Again, insoluble components were removed by filtration and the filtrate evaporated. The obtained residue was washed thoroughly with water and dried.

Workup

  1. customremoved by filtration
  2. customWater was evaporated from the filtrate
  3. additionthe residue dispersed in pyridine
  4. customAgain, insoluble components were removed by filtration
  5. customthe filtrate evaporated
  6. washThe obtained residue was washed thoroughly with water
  7. customdried

Sources & evidence

ORD record
ord-ad8dbdad0146494a970eef6ec143b9bc
Source dataset
uspto-grants-2010_08
Patent number
US07786113B2

Reaction notes

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