反应详情

1.0 g 2,3-diamino-5-nitropyridine and 1.125 g 4-methylsulfanylbenzoic acid in 20 ml polyphosphoric acid were heated to 160° C. with stirring for 15 hrs. The mixture was cooled and poured into water. The pH was adjusted to 4-5 by addition of sodium hydroxide and the precipitate collected by filtration. The filtration residue was stirred in 50 ml pyridine at 60° C., cooled and insoluble components removed by filtration. The filtrate was evaporated and the residue used without further purification in the next steps.

1. temperatureThe mixture was cooled
2. filtrationthe precipitate collected by filtration
3. stirringThe filtration residue was stirred in 50 ml pyridine at 60° C.
4. temperaturecooled
5. custominsoluble components removed by filtration
6. customThe filtrate was evaporated
7. customthe residue used without further purification in the next steps