HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis(2-Methoxyethyl)amine → HCID 178495927, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis(2-Methoxyethyl)amine | HCID 2383 | — |
| Reactant | HCID 178526788 | HCID 178526788 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178495927 | HCID 178495927 | — |
Reaction Steps
0.5 g 2-(3,4-Difluoro-phenyl)-6-nitro-3H-imidazo[4,5-b]pyridine, 0.1 ml NMP and 0.51 g bis(2-methoxyethyl)-amine were heated to 170° C. with stirring for 18 hrs. Volatile materials were removed under vacuum and the residue purified by chromatography, first on silica in dichloromethane/methanol mixtures, and subsequently by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786113B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-c65b725c95794656980eb21e3b395bb7 |
| Source note | uspto-grants-2010_08 |