1,1'-Carbonyldiimidazole → HCID 178495560, Verbindung

HRID 506603Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 506603
[CH:1]([O:4][C:5]([NH:7][C:8]1[CH:9]=[C:10]2[N:16]=[C:15]([C:17]3[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=3)[C:20](O)=[O:21])[NH:14][C:11]2=[N:12][CH:13]=1)=[O:6])([CH3:3])[CH3:2].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:38][CH:39]([CH2:43][O:44][CH3:45])[CH2:40][O:41][CH3:42]>CN(C=O)C>[CH:1]([O:4][C:5](=[O:6])[NH:7][C:8]1[CH:9]=[C:10]2[N:16]=[C:15]([C:17]3[CH:25]=[CH:24][CH:23]=[C:19]([C:20](=[O:21])[NH:38][CH:39]([CH2:43][O:44][CH3:45])[CH2:40][O:41][CH3:42])[CH:18]=3)[NH:14][C:11]2=[N:12][CH:13]=1)([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 682631,1'-CarbonyldiimidazoleHCID 15141601,3-dimethoxypropan-2-amineHCID 178459833HCID 178459833, Verbindung

Produkt 1

HCID 178495560HCID 178495560, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

25 mg (0.07 mmol) of the acid from example 11-1 in 1 ml dry DMF were treated with 18 mg (0.11 mmol) 1,1′-carbonyl-diimidazole at room temperature for 2 hrs. 13 mg (0.11 mmol) 2-amino-1,3-dimethoxypropan were added and stirring was continued for 4 hrs. The solvent was removed under vacuum, the residue dissolved in dichloromethane and washed with aqueous sodium carbonate solution. The dichloromethane phase was evaporated and the residue purified by chromatography on silica in dichloromethane/methanol mixtures.

Aufarbeitung

  1. customThe solvent was removed under vacuum
  2. dissolutionthe residue dissolved in dichloromethane
  3. washwashed with aqueous sodium carbonate solution
  4. customThe dichloromethane phase was evaporated
  5. customthe residue purified by chromatography on silica in dichloromethane/methanol mixtures

Quellen und Nachweise

ORD-Eintrag
ord-b51496d90e71417bbb0326f6258256ed
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786113B2

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