HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-3-Pyrrolidinol → 8-[3-((R)-3-Hydroxy-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-3-Pyrrolidinol | HCID 2759337 | — |
| Reactant | 8-(3-(piperidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16679519 | — |
| Product | 8-[3-((R)-3-Hydroxy-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one | HCID 16679610 | 22% |
Reaction Steps
The title compound was synthesized in analogy to example 2, from 8-(3-chloro-propoxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 2, intermediate) and (R)-3-hydroxypyrrolidine (commercially available), to give the desired product as colorless solid (22%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786109B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-d505441bedb44d68b662d691c7bbfe3f |
| Source note | uspto-grants-2010_08 |