HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-Methylpyrrolidine → (R)-8-(3-(2-methylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-Methylpyrrolidine | HCID 641544 | — |
| Reactant | 8-(3-(piperidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16679519 | — |
| Product | (R)-8-(3-(2-methylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16122898 | 16% |
Reaction Steps
The title compound was synthesized in analogy to example 2, from 8-(3-chloro-propoxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 2, intermediate) and (R)-2-methylpyrrolidine (commercially available) to give the desired product as a light red solid (16%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786109B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-c50c56160838411799baebba6e89c803 |
| Source note | uspto-grants-2010_08 |