Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dimethylpyrrolidine, (2R,5R)- → 8-(3-((2S,5S)-2,5-dimethylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dimethylpyrrolidine, (2R,5R)- | HCID 641767 | — |
| 반응물 | 8-(3-(piperidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16679519 | — |
| 생성물 | 8-(3-((2S,5S)-2,5-dimethylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16679611 | 7% |
반응 단계
The title compound was synthesized in analogy to example 2, from 8-(3-chloro-propoxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 2, intermediate) and (2R,5R)-(−)-trans-2,5-dimethylpyrrolidine (commercially available), to give the desired product as a white solid (7%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07786109B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-224bb1ff10e84f6188682ba4ecac6627 |
| 출처 메모 | uspto-grants-2010_08 |