HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 8-(1-isopropylpiperidin-4-yloxy)-2-(2,2,2-trifluoroethyl)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,2,2-Trifluoroethyl trifluoromethanesulfonate | HCID 80366 | — |
| Reactant | 8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16679518 | — |
| Product | 8-(1-isopropylpiperidin-4-yloxy)-2-(2,2,2-trifluoroethyl)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16679706 | 19% |
Reaction Steps
The title compound was synthesized in analogy to example 17, from 8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 1), sodium hydride and 2,2,2-trifluoroethyl trifluoromethanesulfonate, to give the title compound as a white solid (19%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786109B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-ddd97007f1d04bd09e2c5bbfc0de0621 |
| Source note | uspto-grants-2010_08 |