HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 16678420, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| Reactant | 8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16679518 | — |
| Product | HCID 16678420 | HCID 16678420 | 74% |
Reaction Steps
The title compound was synthesized in analogy to example 17, from 8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 1), sodium hydride and 3-(trifluoromethyl)benzyl bromide, to give the desired product as a white solid (74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786109B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-885583fdacee40a1b9daa5ece6df1d63 |
| Source note | uspto-grants-2010_08 |