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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 506708Generated: October 28, 2026

Sodium hydride → HCID 16678620, compound

https://huagongshe.com/reaction/506708

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant4-(Chloromethyl)pyridinium chlorideHCID 74570—
Reactant8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-oneHCID 16679518—
ProductHCID 16678620HCID 1667862074%

Reaction Steps

The title compound was synthesized in analogy to example 17, from 8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 1), sodium hydride (2.4 equivalents) and 4-(chloromethyl)pyridine hydrochloride, to give the desired product as a light yellow solid (74%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07786109B2
Source datasetuspto-grants-2010_08
ORD IDord-7565e279d6924c0e92a605d15d6fcd85
Source noteuspto-grants-2010_08