HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-Bromoethyl)benzene → (RS)-8-(1-Isopropyl-piperidin-4-yloxy)-2-(1-phenyl-ethyl)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-Bromoethyl)benzene | HCID 11454 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one | HCID 16679518 | — |
| Product | (RS)-8-(1-Isopropyl-piperidin-4-yloxy)-2-(1-phenyl-ethyl)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one | HCID 16678621 | 67% |
Reaction Steps
The title compound was synthesized in analogy to example 17, from 8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 1), sodium hydride and (1-bromoethyl)benzene, to give the desired product as a white foam (67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786109B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-57cb2600bad842ef82ade26180bda592 |
| Source note | uspto-grants-2010_08 |