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Sodium hydride → 9-Benzyloxy-2-cyclopropylmethyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Bromomethylcyclopropane | HCID 81503 | — |
| 反応物 | 9-(1-Isopropyl-piperidin-4-yloxy)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one | HCID 16679701 | — |
| 生成物 | 9-Benzyloxy-2-cyclopropylmethyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one | HCID 68465711 | — |
反応手順
The title compound was synthesized in analogy to example 17, from 9-benzyloxy-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one (example 15, intermediate b)), 1-(bromomethyl)cyclopropane and sodium hydride, to give the compound as a white solid (76%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07786109B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-489145aca8594353944d649bfaaf05a3 |
| 出典メモ | uspto-grants-2010_08 |