(2S)-2-methylpyrrolidine → 7-[3-((S)-2-Methyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

HRID 506744노트

반응식

HRID 506744 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:18]=[C:17]2[C:9]([N:10]3[C:15](=[CH:16]2)[C:14](=[O:19])[NH:13][CH2:12][CH2:11]3)=[N:8][CH:7]=1.[CH3:20][C@H:21]1[CH2:25][CH2:24][CH2:23][NH:22]1>>[CH3:20][C@H:21]1[CH2:25][CH2:24][CH2:23][N:22]1[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:18]=[C:17]2[C:9]([N:10]3[C:15](=[CH:16]2)[C:14](=[O:19])[NH:13][CH2:12][CH2:11]3)=[N:8][CH:7]=1

참가 물질

3

반응물 2

HCID 6999702(2S)-2-methylpyrrolidineHCID 684627297-(3-chloro-propoxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

생성물 1

HCID 166790307-[3-((S)-2-Methyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one수율 19%

실험 절차

The title compound was synthesized in analogy to example 2, from 7-(3-chloro-propoxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one and (S)-2-methylpyrrolidine (commercially available), to give the desired product as a colorless solid (19%).

출처 및 근거

ORD 기록
ord-14e87fd028784e908ea9ad8c3011356b
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786109B2

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