HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dimethylpyrrolidine, (2R,5R)- → 7-[3-((2r,5r)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2h-2,4a,5-triaza-fluoren-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dimethylpyrrolidine, (2R,5R)- | HCID 641767 | — |
| Reactant | 7-[3-((S)-2-Methyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one | HCID 16679030 | — |
| Product | 7-[3-((2r,5r)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2h-2,4a,5-triaza-fluoren-1-one | HCID 16679123 | 19% |
Reaction Steps
The title compound was synthesized in analogy to example 2, from 7-(3-chloro-propoxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one (example 85, intermediate) and (2R,5R)-(−)-trans-2,5-dimethylpyrrolidine (commercially available), to give the desired product as a colorless solid (19%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786109B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-aa0b95eacb774d4eb011638974119b28 |
| Source note | uspto-grants-2010_08 |