HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-Cyclopropylmethyl-7-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 7-(1-Isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one | HCID 16679029 | — |
| Product | 2-Cyclopropylmethyl-7-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one | HCID 68464033 | 85% |
Reaction Steps
The title compound was synthesized in analogy to example 17, from 7-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one (example 84), 1-(bromomethyl)cyclopropane and sodium hydride, to give the desired product as a colorless solid (85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786109B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-9dc41778497e412a985607fcadfeedee |
| Source note | uspto-grants-2010_08 |