Potassium Carbonate → HCID 68471130, compound

Participants

Reaction Conditions

Reaction Steps

Add 1-methylpiperazine (3.5 equiv., 35.2 mg, 39.1 μmol, 0.352 mmol) and K2CO3 (13.8 mg, 0.10 mmol) to bisazaindole 32 (64 mg, 0.10 mmol) in CH3CN (6.0 mL). After heating at 60° C. for 48 h, the reaction medium is concentrated under vacuum and the residue of raw product is submitted to flash chromatography on SiO2 (MeOH at 2-4%/CH2Cl2/heptane) to give 35 (40 mg, 64.3%) as a white solid: 1H NMR (CDCl3) δ 8.23 (d, 1H, J=5.4 Hz), 7.68 (d, 2H, J=8.1 Hz), 7.61 (s, 1H), 7.10 (m, 5H), 4.25 (t, 2H, J=6.6 Hz), 4.01 (s, 3H), 3.97 (s, 3H), 2.83 (t, 2H, J=6.9 Hz), 2.57-2.46 (m broad, 8H), 2.28 (s, 3H), TLC (MeOH at 10%/CH2Cl2, 0.25% of NH3) Rf=0.45, m/z obs.=609.04 (M+1).

Provenance & Evidence