HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 4-Chloro-5-fluoro-1H-pyrrolo(2,3-b)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178526273 | HCID 178526273 | — |
| Product | 4-Chloro-5-fluoro-1H-pyrrolo(2,3-b)pyridine | HCID 49761611 | — |
Reaction Steps
4-Chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine can be obtained as in example 4 stage 4(b) but starting from 1.7 g of 5-fluoro-1H-pyrrolo[2,3-b]pyridine 7-oxide in 10 cm3 of phosphorus oxychloride. In this way, 1.3 g of 4-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine is obtained as a solid with the following characteristics:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786114B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-bba8f1fc49fe4e189565ea6513710e81 |
| Source note | uspto-grants-2010_08 |