Potassium Hydroxide → HCID 68466502, compound

Participants

Reaction Steps

A suspension of 0.2 g of 3-[4-chloro-5-fluoro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-5,6-dimethoxy-1H-pyrrolo[3,2-b]pyridine and 0.580 g of potassium hydroxide in 40 cm3 of methanol is refluxed for about 5 hours. After concentrating under reduced pressure (13 kPa), the solid is taken up in 50 cm3 of water, filtered off by suction and washed with 10 cm3 of water. After recrystallization from 40 cm3 of acetonitrile, 0.110 g of 3-[4-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl]-5,6-dimethoxy-1H-pyrrolo[3,2-b]pyridine is obtained as a solid with the following characteristics:

Provenance & Evidence