Dichloromethane → HCID 86618634, compound

Participants

Reaction Steps

3-[4-Chloro-5-fluoro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-5,6-dimethoxy-1-[3-(4-methylperhydro-1,4-diazepin-1-yl)propyl]-1h-pyrrolo[3,2-b]pyridine can be prepared as in example 11, stage 11(c), but starting with 0.300 g of 3-[4-chloro-5-fluoro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1-(3-iodopropyl)-5,6-dimethoxy-1H-pyrrolo[3,2-b]pyridine and 0.512 g of 1-methylperhydro-1,4-diazepine in 40 cm3 of dichloromethane. After flash chromatography on a column of silica [eluent: chloroform/methanol/28% aqueous ammonia (24/3/0.5 by volume)], 0.145 g of 3-[4-chloro-5-fluoro-1-(toluene-4-sulfonyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-5,6-dimethoxy-1-[3-(4-methylperhydro-1,4-diazepin-1-yl)propyl]-1H-pyrrolo[3,2-b]pyridine is thus obtained as a resin with the following characteristics:

Provenance & Evidence