Potassium Hydroxide → HCID 68465767, compound

HRID 506796Notes

Reaction equation

HRID 506796 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][C:9]([C:11]3[C:15]4=[N:16][C:17]([O:22][CH3:23])=[C:18]([O:20][CH3:21])[CH:19]=[C:14]4[N:13]([CH2:24][CH2:25][CH2:26][N:27]4[CH2:32][CH2:31][CH:30](O)[CH2:29][CH2:28]4)[CH:12]=3)=[CH:10][C:3]=12.ClC1C=CN=C2N(S(C3C=CC(C)=CC=3)(=O)=O)C(C3C4=N[C:50](OC)=[C:51]([O:53]C)C=C4N(CCCN4CCC(O)CC4)C=3)=CC=12.[OH-].[K+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][C:9]([C:11]3[C:15]4=[N:16][C:17]([O:22][CH3:23])=[C:18]([O:20][CH3:21])[CH:19]=[C:14]4[N:13]([CH2:24][CH2:25][CH2:26][N:27]4[CH2:32][CH2:31][CH:30]([CH2:50][CH2:51][OH:53])[CH2:29][CH2:28]4)[CH:12]=3)=[CH:10][C:3]=12

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 68467041HCID 68467041, compoundHCID 68471787HCID 68471787, compound

Product 1

HCID 68465767HCID 68465767, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-{3-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxypyrrolo[3,2-b]pyridin-1-yl]propyl}piperidin-4-ol can be prepared as in example 5, stage 5(d), but starting with 0.368 g of 1-(3-{3-[4-chloro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-5,6-dimethoxypyrrolo[3,2-b]pyridin-1-yl}propyl)-piperidin-4-ol and 0.857 g of potassium hydroxide in 25 cm3 of methanol. 0.188 g of 2-(1-{3-[3-(4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxypyrrolo[3,2-b]pyridin-1-yl]propyl}piperidin-4-yl)ethanol is thus obtained with the following characteristics:

Sources & evidence

ORD record
ord-22e4966809b04da89103da66b1988302
Source dataset
uspto-grants-2010_08
Patent number
US07786114B2

Reaction notes

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