Potassium Hydroxide → HCID 68465715, compound

HRID 506808Notes

Reaction equation

[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[N:36](S(C4C=CC(C)=CC=4)(=O)=O)[C:16]4=[N:17][CH:18]=[CH:19][C:20]([CH2:21][NH:22][CH2:23][C:24]5[CH:29]=[CH:28][C:27]([N:30]6[CH2:35][CH2:34][O:33][CH2:32][CH2:31]6)=[CH:26][CH:25]=5)=[C:15]4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:47][CH3:48].[OH-].[K+]>>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[NH:36][C:16]4=[N:17][CH:18]=[CH:19][C:20]([CH2:21][NH:22][CH2:23][C:24]5[CH:25]=[CH:26][C:27]([N:30]6[CH2:31][CH2:32][O:33][CH2:34][CH2:35]6)=[CH:28][CH:29]=5)=[C:15]4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:47][CH3:48]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 68468333[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-(4-morpholin-4-yl-benzyl)amine

Product 1

HCID 68465715HCID 68465715, compoundYield 56.4%

Procedure

The product is prepared by following the procedure described in example 34, stage (k), starting with 0.03 g of [2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-(4-morpholin-4-yl-benzyl)amine instead of the cyclopropyl-[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amine used in example 34, stage (k) and 0.18 cm3 of 5N potassium hydroxide. 0.013 g of [2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-(4-morpholin-4-yl-benzyl)amine is obtained with the following characteristics:

Workup

customThe product is prepared

Sources & evidence

ORD record: ord-64d74eb0d4684aa5901697ec98c2ab0c
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07786114B2

Reaction notes

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