HRID506808

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

结构：COc1cc2c(nc1OC)c(-c1cc3c(CNCc4ccc(N5CCOCC5)cc4)ccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C

HCID68468333

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(nc1OC)c(-c1cc3c(CNCc4ccc(N5CCOCC5)cc4)ccnc3[nH]1)cn2C

HCID68465715

未命名化合物

收率 56.4%

PROCEDURE

实验过程

The product is prepared by following the procedure described in example 34, stage (k), starting with 0.03 g of [2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-(4-morpholin-4-yl-benzyl)amine instead of the cyclopropyl-[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amine used in example 34, stage (k) and 0.18 cm3 of 5N potassium hydroxide. 0.013 g of [2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-(4-morpholin-4-yl-benzyl)amine is obtained with the following characteristics:

WORKUP

后处理

customThe product is prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-64d74eb0d4684aa5901697ec98c2ab0c
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07786114B2
来源说明: uspto-grants-2010_08

反应 SMILES

[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[N:36](S(C4C=CC(C)=CC=4)(=O)=O)[C:16]4=[N:17][CH:18]=[CH:19][C:20]([CH2:21][NH:22][CH2:23][C:24]5[CH:29]=[CH:28][C:27]([N:30]6[CH2:35][CH2:34][O:33][CH2:32][CH2:31]6)=[CH:26][CH:25]=5)=[C:15]4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:47][CH3:48].[OH-].[K+]>>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[NH:36][C:16]4=[N:17][CH:18]=[CH:19][C:20]([CH2:21][NH:22][CH2:23][C:24]5[CH:25]=[CH:26][C:27]([N:30]6[CH2:31][CH2:32][O:33][CH2:34][CH2:35]6)=[CH:28][CH:29]=5)=[C:15]4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:47][CH3:48]