反应详情

To a solution of 3-bromo-4-fluorobenzaldehyde (5.0 g, 24.6 mmol) in H2SO4 (25 mL) at 0° C. was added nitric acid (3 mL) in H2SO4 (30 mL), dropwise. The resulting mixture was warmed to room temperature overnight. The resulting solution was then poured slowly over ice and filtered to collect the yellow precipitate. The precipitate was washed with H2O and dried, then purified by silica gel chromatography eluted with a solvent mixture of ethyl acetate and heptanes from 0:100 to 25:75 to yield a light yellow solid.

1. additionThe resulting solution was then poured slowly over ice
2. filtrationfiltered
3. customto collect the yellow precipitate
4. washThe precipitate was washed with H2O
5. customdried
6. custompurified by silica gel chromatography
7. washeluted with a solvent mixture of ethyl acetate and heptanes from 0:100 to 25:75
8. customto yield a light yellow solid