反应详情

温度

0 °C

Sulfuric acid (108 mL) and 3-bromobenzaldehyde (25 g, 0.135 mol) were cooled to 0° C. in a flask. Potassium nitrate (14.3 g, 0.14 mol) was added to the resulting mixture, portion wise over 1 h. The resulting mixture was stirred an additional 2 h at 0° C. For work up, the resulting mixture was poured into 2 L of ice and then filtered to yield a solid. The solid was purified by silica chromatography (330 g, 30% Et2O/heptane) to yield a residue, which was recrystallized from EtOAc/heptane to yield a solid.

1. filtrationfiltered
2. customto yield a solid
3. customThe solid was purified by silica chromatography (330 g, 30% Et2O/heptane)
4. customto yield a residue, which
5. customwas recrystallized from EtOAc/heptane
6. customto yield a solid