Hydrochloric Acid → HCID 59432792, compound

Participants

Reaction Steps

To a solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (100 mg, 0.5 mmol) in MeOH (5 ml) was added NaBH3 CN (32 mg, 0.5 mmol, 1 eq.). The pH of the reaction mixture was adjusted to 5.5 by addition of 5N HCl and stirred for 48 hrs at RT under an inert atmosphere. The solvent was removed under reduced pressure and the crude was taken-up in AcOEt (150 ml). The organic layer was washed with NaHCO3 (10 ml) and with brine (10 ml) and was dried over MgSO4. The solvent was removed under vacuo to give the expected 4-(methyl-propyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (106 mg, 82% yield).

Provenance & Evidence