1-(3,5-Dichlorophenyl)piperazine → 3-{4-[4-(3,5-dichlorophenyl)-piperazine-1-yl]-butyl}-3-ethyl-5-fluoro-1,3-dihydro-2H-indol-2-one

HRID 506940Notes

Reaction equation

HRID 506940 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([CH2:17][CH3:18])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([F:15])[CH:13]=2)[NH:8][C:7]1=[O:16].[Cl:19][C:20]1[CH:21]=[C:22]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:23]=[C:24]([Cl:26])[CH:25]=1>>[Cl:26][C:24]1[CH:23]=[C:22]([N:27]2[CH2:32][CH2:31][N:30]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]3([CH2:17][CH3:18])[C:14]4[C:9](=[CH:10][CH:11]=[C:12]([F:15])[CH:13]=4)[NH:8][C:7]3=[O:16])[CH2:29][CH2:28]2)[CH:21]=[C:20]([Cl:19])[CH:25]=1

Participants

3

Reactant 2

HCID 27360671-(3,5-Dichlorophenyl)piperazineHCID 670412173-(4-Chlorobutyl)-3-ethyl-5-fluoro-1,3-dihydro-2H-indol-2-one

Product 1

HCID 684651573-{4-[4-(3,5-dichlorophenyl)-piperazine-1-yl]-butyl}-3-ethyl-5-fluoro-1,3-dihydro-2H-indol-2-one

Procedure

The title compound is prepared according to process H by applying processing method 1 from 3-(4-chlorobutyl)-3-ethyl-5-fluoro-1,3-dihydro-2H-indol-2-one and 1-(3,5-dichlorophenyl)-piperazine.

Sources & evidence

ORD record
ord-7a74ea2a8e844a61b02a2b9677708dc6
Source dataset
uspto-grants-2010_08
Patent number
US07786129B2

Reaction notes

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