(4-Amino-3'-chloro-biphenyl-3-yl)-cyclopropyl-methanone → HCID 22736625, compound

HRID 50698Notes

Reaction equation

HRID 50698 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)=[CH:4][C:3]=1[C:15]([CH:17]1[CH2:19][CH2:18]1)=[O:16].[CH:20]1([Mg]Br)[CH2:22][CH2:21]1>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)=[CH:4][C:3]=1[C:15]([CH:20]1[CH2:22][CH2:21]1)([CH:17]1[CH2:18][CH2:19]1)[OH:16]

Participants

3

Reactant 2

HCID 23509605(4-Amino-3'-chloro-biphenyl-3-yl)-cyclopropyl-methanoneHCID 178418630HCID 178418630, compound

Product 1

HCID 22736625HCID 22736625, compound

Procedure

(4-Amino-3′-chloro-biphenyl-3-yl)-dicyclopropyl-methanol (mp 90-92° C.; MS ((+)ESI) m/z 314 (M+H)+.) was prepared from (4-amino-3′-chloro-biphenyl-3-yl)-cyclopropyl-methanone and cyclopropylmagnesium bromide according to Example 41.

Sources & evidence

ORD record
ord-b1cd9084cdec4146813e37bf30419a1c
Source dataset
uspto-grants-2004_03
Patent number
US06713478B2

Reaction notes

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