HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 507021Generated: October 31, 2026
Ammonium Chloride → HCID 59432334, compound
https://huagongshe.com/reaction/507021
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 86615652 | HCID 86615652 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 59432334 | HCID 59432334 | — |
Reaction Steps
Add a solution of (+/−)-isopropyl 5-[(3,5-bistrifluoromethylbenzyl)-cyanoamino]-7-bromo-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate in anhydrous N,N-dimethylformamide dropwise to a stirred suspension of sodium azide and ammonium chloride in anhydrous N,N-dimethylformamide and heat the resulting yellow mixture at 110° C. under nitrogen. Dilute the cooled mixture with water and 2 N NaOH and wash with diethyl ether. Acidify with 5 N HCl, collect the precipitate and wash with water to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07786108B2 |
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| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-1c60f1aea8bc477fa5d83b2427c6c116 |
|---|
| Source note | uspto-grants-2010_08 |
|---|
