HCID 86615656, compound → HCID 11520462, compound

Participants

Reaction Steps

Heat the mixture of (4-{5-[(3,5-Bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-cyclohexyl)-acetic acid benzyl ester (0.0340 g, 0.0427 mmol) in 5.0 N NaOH (1 mL) and methanol (1 mL) at 60° C. for 2 h. Evaporate the solvents and re-dissolve in water (10 mL). Adjust to pH=2 by adding 5.0 N HCl. Extract with ethyl acetate (2×10 mL). Combine organic layers, dry over anhydrous sodium sulfate and filter. Remove the solvent under reduced pressure. Chromatograph the residue over silica gel, eluting with ethyl acetate/hexanes (0-50%), to provide the title compound as a colorless oil (0.0200 g, 67%). MS (ES+): MS (ES+): 707 (M+H).

Provenance & Evidence