HCID 59432332, compound → HCID 11692526, compound

Participants

Reaction Steps

Purge a solution of (S)-[5-(2-Benzyloxy-ethyl)-3,5,6,7,8,9-hexahydro-1H-2-oxa-5-aza-cyclohepta[f]inden-9-yl]-(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amine (0.14 mmol) in methanol (20 mL) with nitrogen and add a catalytic amount of Pd/C. Purge the resulting mixture with hydrogen and stir at room temperature for 5 h. Purge the reaction with nitrogen, filter through Celite®, and wash with methanol (50 mL). Remove solvent under vacuum. Chromatograph the crude product over silica gel, eluting with ethyl acetate/hexane (5-100%) to provide the title compound as a colorless foam. MS (ES+): 557 (M+H).

Provenance & Evidence