HCID 59432463, compound → HCID 59432482, compound

Participants

Reaction Steps

To a solution of (S)-2-(2-{5-[[1-(2-Benzyloxy-ethyl)-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-(3,5-bis-trifluoromethyl-benzyl)-amino]-tetrazol-2-yl}-ethyl)-isoindole-1,3-dione (Example 126, Step 3) (0.09 mmol) in methanol (20 mL), add a catalytic amount of 10% Pd/C after purging with nitrogen. Purge the reaction with a balloon of hydrogen and stir under a balloon of hydrogen for 14 h. Purge the reaction with nitrogen and filter through Celite®. Collect the filtrate and remove solvent under vacuum. Chromatograph the reaction over silica gel eluting with ethyl acetate/hexane (15-45%) to afford the title compound.

Provenance & Evidence