HCID 59432474, compound → HCID 59432386, compound

Participants

Reaction Conditions

Reaction Steps

Add a solution of borane-THF complex in THF (1.0 M, 0.2 mL, 0.2 mmol) to 5-[(3,5-Bis-trifluoromethyl-benzoyl)-pyridin-3-yl-amino]-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylic acid isopropyl ester (90.1 mg, 0.139 mmol) in THF (1.6 mL). Heat in a sealed tube (70° C.) for 14 h. Add saturated aqueous sodium bicarbonate (5 mL) and extract with EtOAc (3×5 mL). Dry (MgSO4), concentrate, and purify via column chromatography (silica gel; 10% to 20% to 25% EtOAc:hexanes) to give 19 mg (22%) of the title compound as a yellow solid. APCI MS m/z 634 [M+H]+.

Provenance & Evidence