HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butylamine → 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid butyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid | HCID 68463846 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid butyl-amide | HCID 11698937 | — |
Reaction Steps
0.16 mmol of 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid were dissolved in 1 ml THF with 1 eq. DIC. After 15 min 1.5 eq of butylamine was added and the reaction stirred at room temperature for 16 h. The crude material was purified via reversed phase preparative HPLC. MS(ISP) 498.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786128B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-8926aea73352411e99524f1405ec1682 |
| Source note | uspto-grants-2010_08 |