HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylcarbodiimide → 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid [2-(3-trifluoromethyl-phenyl)-ethyl]-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylcarbodiimide | HCID 12734 | — |
| Edukt | Phenethylamine, m-trifluoromethyl- | HCID 104223 | — |
| Edukt | 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid | HCID 68463846 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid [2-(3-trifluoromethyl-phenyl)-ethyl]-amide | HCID 86623359 | — |
Reaktionsschritte
0.16 mmol of 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid were dissolved in 1 ml THF with 1 eq. DIC. After 15 min 1.5 eq of 3-trifluoromethylphenethylamine were added and the reaction stirred at room temperature for 16 h. The crude material was purified via reversed phase preparative HPLC MS(ISP): 614.6 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07786128B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-04c92695a53647fe9d8ec8e5810d8964 |
| Quellennotiz | uspto-grants-2010_08 |