HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 507228Generated: October 25, 2026
Triethylamine → 2-Phenoxymethyl-1H-indole-5-carboxylic acid methyl ester
https://huagongshe.com/reaction/507228
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (Prop-2-ynyloxy)benzene | HCID 83613 | — |
| Reactant | Methyl 4-amino-3-iodobenzoate | HCID 4104649 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Phenoxymethyl-1H-indole-5-carboxylic acid methyl ester | HCID 59732213 | — |
Reaction Steps
Resin bound 4-amino-3-iodo-benzoic acid methyl ester was suspended in DMF and treated with 15.6 g of phenyl propargylether, 60 ml of triethylamine and catalytic amounts of CuI and bis(triphenylphosphine)palladium(II) chloride. The resin was shaken for 6 h at 50° C. and washed subsequently with DMF, isopropanol/water and diethylether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07786128B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-cf7969adc71142b7b74277fa3a117ae2 |
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| Source note | uspto-grants-2010_08 |
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