2-Aminothiazole → HCID 59432926, compound

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Reaction Steps

1-Formyl-1,2,3,4-tetrahydro-quinoline-6-sulfonyl chloride (10.0 g, 0.04 mol) was added to a stirring solution of 2-aminothiazole (3.9 g, 0.04 mol) in pyridine (15 mL), under N2 at 0° C. This mixture was allowed to warm to room temperature and was stirred for 19 hours. The mixture was purified via silica gel chromatography using 10% MeOH in CH2Cl2 to obtain the sulfonamide (1.50 g, 0.005 mmol, 12% yield). LC/MS (10-99%) M/Z: M+1 obs=324.3; tR=2.21 min.

Provenance & Evidence