2-Aminothiazole → HCID 59432955, compound

Participants

Reaction Conditions

Reaction Steps

2-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride (8.4 g, 0.03 mol) was dissolved in pyridine (10 mL) and heated to 60° C. 2-Aminothiazole (2.5 g, 0.03 mol) was added slowly and the reaction mixture was stirred at 60° C. for 1 hour. Complete conversion to product was observed by LC/MS (10-99% CH3CN). The crude reaction mixture was then purified via column chromatography using 5% MeOH/CH2Cl2 to obtain the sulfonamide (7.0 g, 0.018 mmol, 70% yield). LC/MS (10-99% CH3CN), M/Z: M+1 obs=392.0; tR=2.65 min.

Provenance & Evidence