Potassium Hydroxide → HCID 28263319, compound

HRID 507238Notes

Reaction equation

HRID 507238 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][S:7]([C:10]1[CH:19]=[C:18]2[C:13]([CH2:14][CH2:15][N:16](C(=O)C(F)(F)F)[CH2:17]2)=[CH:12][CH:11]=1)(=[O:9])=[O:8].[OH-].[K+]>CCO>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][S:7]([C:10]1[CH:19]=[C:18]2[C:13]([CH2:14][CH2:15][NH:16][CH2:17]2)=[CH:12][CH:11]=1)(=[O:9])=[O:8]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 59432955HCID 59432955, compound

Product 1

HCID 28263319HCID 28263319, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid thiazol-2-ylamide (5.0 g, 0.013 mol), was suspended in EtOH (50 mL). After slowly adding KOH (3.0 g, 0.05 mol) over 5 minutes, the solution started to clear. After an additional 10 minutes of stirring, the formed precipitate was filtered, washed several times with EtOH, and dried under high vacuum to give the amine (3.0 g, 0.012 mmol, 95% yield). LC/MS (10-99% CH3CN), M/Z: M+1 obs=296.2; tR=0.66 min.

Workup

  1. filtrationthe formed precipitate was filtered
  2. washwashed several times with EtOH
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-3d4594a84ab8425a81429fb772fc1cb3
Source dataset
uspto-grants-2010_08
Patent number
US07786137B2

Reaction notes

Loading…