참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phenacyl bromide | HCID 6259 | — |
| 반응물 | tert-Butyl 4-carbamothioylpiperidine-1-carboxylate | HCID 2735648 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-(4-Phenyl-thiazol-2-yl)-piperidine hydrobromide | HCID 68462453 | 96% |
반응 단계
A mixture of 1 g (4.1 mmol) 4-thiocarbamoyl-piperidine-1-carboxylic acid tert-butyl ester (commercially available) and 0.816 g (4.1 mmol) 2-bromo-1-phenyl-ethanone (commercially available) in 10 ml methanol was stirred at 70° C. for 22 h. After evaporation to dryness the residue was suspended in diethyl ether and filtered. The residue washed with diethyl ether and dried under vacuum to yield 1.279 g (96%) of the title compound in white crystalline form. (m/e): 245.2 (MH+(−HBr); 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07786143B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_08 |
|---|
| ORD ID | ord-101cd7a6e6764b55be8e8e773303f105 |
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| 출처 메모 | uspto-grants-2010_08 |
|---|
