Hydrochloric Acid → HCID 16062722, compound

Participants

Reaction Steps

A mixture of 29.1 mg (0.1 mmol) 2-(1-isopropyl-piperidin-4-yl)-thiazole-4-carboxylic acid; hydrochloride, 35.3 mg (0.11 mmol) 2-(1H-benzotriazol-1-yl-1,1,3,3-tetramethyl uronium tetrafluoroborate, 14.03 mg (0.11 mol) 4-chloroaniline and 140 ul (0.5 mmol) N-ethyldiisopropylamine in 1 ml DMF was reacted at room temperature for a prolonged period of time. The mixture was treated with 50 μl triethylamine and subjected to preparative HPLC purification on reversed phase material eluting with a gradient of acetonitrile/water/triethyamine (0.05%). The product fractions were evaporated to dryness to yield 10.6 mg (29%) of the title compound. MS (m/e): 364.1 (MH+, 100%).

Provenance & Evidence