HRID507412

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID179502

2-(2-Methoxyphenyl)acetyl chloride

C9H9ClO2

结构：CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1CC(=O)c1ccc(N)cc1

HCID68468184

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1CC(=O)Nc1ccc(C(O)CN2C(=O)C(c3ccccc3)(c3ccccc3)N=C2C)cc1

HCID68463125

未命名化合物

PROCEDURE

实验过程

Synthesis in analogy to Example 8 and Example 19 starting from 3-[2-(4-amino-phenyl)-2-oxo-ethyl]-2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one and (2-methoxy-phenyl)-acetyl chloride to yield N-{4-[1-hydroxy-2-(2-methyl-5-oxo-4,4-diphenyl-4,5-dihydro-imidazol-1-yl)-ethyl]-phenyl}-2-(2-methoxy-phenyl)-acetamide. LC/MS at 254 nm; [M+H] 535: Rt=3.003 min.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7c788c36ae174cd58ca2c56225b60145
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07786155B2
来源说明: uspto-grants-2010_08

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:29])[CH2:9][N:10]2[C:14](=[O:15])[C:13]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:12]=[C:11]2[CH3:28])=[CH:4][CH:3]=1.[CH3:30][O:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[CH2:38][C:39](Cl)=[O:40]>>[OH:29][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:39](=[O:40])[CH2:38][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=2[O:31][CH3:30])=[CH:7][CH:6]=1)[CH2:9][N:10]1[C:14](=[O:15])[C:13]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:12]=[C:11]1[CH3:28]