HRID507414

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2760632

o-tolyl-acetyl chloride

C9H9ClO

结构：CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1CC(=O)c1ccc(N)cc1

HCID68468184

未命名化合物

PRODUCTS

生成物

结构：CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1CC(=O)c1ccc(NC(=O)Cc2ccccc2C)cc1

HCID68464130

未命名化合物

PROCEDURE

实验过程

Synthesis in analogy to Example 8 starting from 3-[2-(4-amino-phenyl)-2-oxo-ethyl]-2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one and o-tolyl-acetyl chloride to yield N-{4-[2-(2-methyl-5-oxo-4,4-diphenyl-4,5-dihydro-imidazol-1-yl)-acetyl]-phenyl}-2-o-tolyl-acetamide. LC/MS at 254 nm; [M+H] 516; Rt 3.526 min.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-421ef9742ce048a998dd619218e7cc69
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07786155B2
来源说明: uspto-grants-2010_08

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:29])[CH2:9][N:10]2[C:14](=[O:15])[C:13]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:12]=[C:11]2[CH3:28])=[CH:4][CH:3]=1.[C:30]1([CH3:40])[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[CH2:36][C:37](Cl)=[O:38]>>[CH3:28][C:11]1[N:10]([CH2:9][C:8]([C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:37](=[O:38])[CH2:36][C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=3[CH3:40])=[CH:7][CH:6]=2)=[O:29])[C:14](=[O:15])[C:13]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:12]=1