HCID 15932422, compound → HCID 68466378, compound

HRID 507420Notes

Reaction equation

HRID 507420 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:29])[CH2:9][N:10]2[C:14](=[O:15])[C:13]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:12]=[C:11]2[CH3:28])=[CH:4][CH:3]=1.[CH3:30][C:31]1[C:35]([CH2:36][C:37](Cl)=[O:38])=[C:34]([CH3:40])[O:33][N:32]=1>>[CH3:30][C:31]1[C:35]([CH2:36][C:37]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8](=[O:29])[CH2:9][N:10]3[C:14](=[O:15])[C:13]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[N:12]=[C:11]3[CH3:28])=[CH:6][CH:7]=2)=[O:38])=[C:34]([CH3:40])[O:33][N:32]=1

Participants

3

Reactant 2

HCID 15932422HCID 15932422, compoundHCID 684681843-[2-(4-Amino-phenyl)-2-oxo-ethyl]-2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one

Product 1

HCID 68466378HCID 68466378, compound

Procedure

Synthesis in analogy to Example 17 starting from 3-[2-(4-amino-phenyl)-2-oxo-ethyl]-2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one and (3,5-dimethyl-isoxazol-4-yl)-acetyl chloride to yield 2-(3,5-dimethyl-isoxazol-4-yl)-N-{4-[2-(2-methyl-5-oxo-4,4-diphenyl-4,5-dihydro-imidazol-1-yl)-acetyl]-phenyl}-acetamide. LC/MS at 254 nm; [M+H] 521; Rt 3,083 min.

Sources & evidence

ORD record
ord-d9c53db50c4b4e809e0efd924b9aa1fd
Source dataset
uspto-grants-2010_08
Patent number
US07786155B2

Reaction notes

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