反应详情

Synthesis in analogy to Example 14 and Example 1 starting from enantiomerically pure 3-[2-(4-amino-2-fluoro-phenyl)-2-oxo-ethyl]-5-(4-fluoro-phenyl)-2-methyl-5-propyl-3,5-dihydro-imidazol-4-one and (3,5-dimethylisoxazol-4-yl)-acetic acid to yield (−)-2-(3,5-dimethyl-isoxazol-4-yl)-N-(3-fluoro-4-{2-[4-(4-fluoro-phenyl)-2-methyl-5-oxo-4-propyl-4,5-dihydro-imidazol-1-yl]-acetyl}-phenyl)-acetamide. LC/MS at 254 nm; [M+H] 523; Rt 3.417 min; optical rotation αD25−1.4°, c=0.5 in methanol.