HCID 68461440, compound → HCID 21015116, compound

HRID 507434Notes

Reaction equation

HRID 507434 reaction equation
C(OC(=O)[NH:7][CH:8]1[C:15](=[O:16])[N:14]2[CH:10]([S:11][CH2:12][CH:13]2[C:17]#[N:18])[CH2:9]1)(C)(C)C>Cl.O1CCOCC1>[NH2:7][CH:8]1[C:15](=[O:16])[N:14]2[CH:10]([S:11][CH2:12][CH:13]2[C:17]#[N:18])[CH2:9]1

Participants

3

Reactant 1

HCID 68461440HCID 68461440, compound

Product 1

HCID 21015116HCID 21015116, compoundYield 30.9%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

Compound 6 (0.6 g, 2.12 mmol) was dissolved in 15 mL 2N HCl/dioxane with stirring. After 2 h, many white solid formed. The above clear liquid was removed and another 20 mL dry ethyl ether was added, stirred and then discarded. The product 7 (0.12 g, 26%) was obtained and dried under reduced pressure. 1H NMR (400 MHz, CDCl3) δ 1.17 (m, 1 H), 2.05-2.15 (m, 1.5 H), 3.10-3.20 (m, 1.5H), 3.40-3.50 (m, 3.5 H), 4.40-4.55 (m, 1.5 H), 4.95 (m, 1 H), 5.22 (m, 1 H), 5.31 (m, 2 H), 5.54 (m, 1 H).

Workup

  1. custommany white solid formed
  2. customThe above clear liquid was removed
  3. additionanother 20 mL dry ethyl ether was added
  4. stirringstirred

Sources & evidence

ORD record
ord-86a38280b250434ab7d00410fd78e565
Source dataset
uspto-grants-2010_08
Patent number
US07786163B2

Reaction notes

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