反应详情

Compound 6 (0.6 g, 2.12 mmol) was dissolved in 15 mL 2N HCl/dioxane with stirring. After 2 h, many white solid formed. The above clear liquid was removed and another 20 mL dry ethyl ether was added, stirred and then discarded. The product 7 (0.12 g, 26%) was obtained and dried under reduced pressure. 1H NMR (400 MHz, CDCl3) δ 1.17 (m, 1 H), 2.05-2.15 (m, 1.5 H), 3.10-3.20 (m, 1.5H), 3.40-3.50 (m, 3.5 H), 4.40-4.55 (m, 1.5 H), 4.95 (m, 1 H), 5.22 (m, 1 H), 5.31 (m, 2 H), 5.54 (m, 1 H).

1. custommany white solid formed
2. customThe above clear liquid was removed
3. additionanother 20 mL dry ethyl ether was added
4. stirringstirred