反应详情

To a solution of 5-bromo-2-fluorotoluene (15 g, 0.079 mole) in CCl4 (150 mL) was added NBS (14.2 g, 0.080 mole). The resulting reaction solution was heated under reflux with the starting material being completely consumed within 2 hr. CCl4 was removed under reduced pressure and the residue was diluted, dissolved in ether, washed with brine (3×), dried over MgSO4, and concentrated. Chromatography in hexane yielded 5-bromo-2-fluorobenzyl bromide. The product was immediately used for the reaction below.

1. customThe resulting reaction solution
2. temperaturewas heated
3. temperatureunder reflux with the starting material
4. custombeing completely consumed within 2 hr
5. customCCl4 was removed under reduced pressure
6. additionthe residue was diluted
7. dissolutiondissolved in ether
8. washwashed with brine (3×)
9. dry with materialdried over MgSO4
10. concentrationconcentrated