Ammonia methanol → HCID 68466014, compound

Participants

Reaction Steps

To a solution of compound 16 (500 mg, 1.28 mmol) in methanol (10 mL) was added NH3-MeOH (10 mL) at room temperature and stirred for 2 h. The solvent was removed in vacuo and afford compound 17 (470 mg, 97.4%). 1H NMR (400 MHz, CDCl3) δ1.42 (s, 9 H), 3.05-3.08 (m, 1 H), 3.35-3.37 (m, 1 H), 3.37-3.49 (m, 1 H), 3.75-3.80 (m, 1 H), 4.89 (bs, 1 H), 4.98 (bs, 1 H), 5.43 (bs, 2 H), 6.57 (bs, 1 H), 7.37-7.50 (m, 5 H). MS (M+1): 378.

Provenance & Evidence